ID: 20136

Nhận biết (M1)

A 2021 paper by Andrew Payne et al. introduced in situ genome sequencing (IGS), which allows simultaneous sequencing and imaging of genomes within biological samples and facilitates analysis of the relationship between a cell’s DNA and structure. Integrating IGS with expansion microscopy, which uses polymers to enlarge small structures for imaging, a team led by Jason Buenrostro later developed expansion in situ genome sequencing (ExIGS)—a technique that also allows simultaneous sequencing and imaging of genomes, but without the limitations on spatial resolution inherent to IGS.

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